It's always best to seek performance improvements by analyzing the application's actions and making changes according to your observations rather than attempting to "tune" the database as a whole. Having said that, however, many database and instance parameters do have a noticeable effect on performance; pay particular attention to such settings as the database cache size, shared pool size, PGA aggregate target, and session_cached_cursors as you run applications for the first time, and adjust them as necessary.
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