Before patching, you must ensure anything that uses that ORACLE_HOME, not just databases, must be shut down. This includes listeners, etc. It is not clear from your question whether you are patching an Oracle database server from 188.8.131.52 to 184.108.40.206 or whether this is a client patch application.
In any case, there are files that the Oracle Universal Installer (OUI) must update but it cannot because the files are in use. I do not know of a way to tell which files are being accessed in a Windows environment (in the Unix environment, there is a command called 'fuser' that will tell you who is accessing a particular file). You might be able to tell whether there are any Oracle-type processes running from the Task Manager. Also ensure that the services you have shut down did not restart automatically.
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