I don't know Progress but as with most all databases, you'll find that knowledge of one will help you learn another more quickly. I'm sure you'd have to learn some new things to support a Progress system.
Interfaces between Progress and Oracle should be able to be accomplished in many different ways: Oracle Transparent Gateway, flat file loads using SQL*Loader, etc. I don't know how "easy" the development of these interfaces would be, but like everything else... where there's a will... there's a way.
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This was first published in November 2002