We've been getting a number of this type of question lately: short, and simple on the surface. Short questions are wonderful, because they leave more room for the answer. Simple questions are even better, as long as they aren't too simple.
In this case, there are two ways to do it.
select distinct col1 , col2 from daTable
This method uses the standard SQL keyword DISTINCT. All distinct combinations of values in two columns are shown. (It could be two, or 10, or even just one column.) The "distinctness" applies to the entire row produced by the query. Every result row is completely distinct.
select col1 , col2 from daTable group by col1 , col2
This method uses the standard SQL keywords GROUP BY. All distinct combinations of values in two columns are shown. (It could be two, or 10, or even just one column.) The "distinctness" applies to the columns in the GROUP BY. Every result row will be completely distinct in those two columns.
If you wanted distinct rows by those two columns, but with additional columns as well, then the question was indeed not as simple as it first appeared. In that case, perhaps the answer DISTINCT is not a function (26 September 2005) may help.
This was first published in April 2007